Similarly, Mutlu et al 19 did not find high MPV values in patients with various types of cancer, but did find low MPV values in patients who experienced thromboembolic events. However, Aksoy et al 18 found lower MPV values in patients with various types of cancers that had metastasized to the bone marrow than in control subjects. Collectively, the above findings suggest that MPV values are significantly increased in patients with malignant disease. Consistent with these studies, our study revealed significantly higher MPV values in patients with thyroid malignancies than in patients with benign thyroid disease. An MCV test may also be used with other tests to help diagnose or monitor certain blood disorders, including anemia. A CBC is a common blood test that measures many parts of your blood, including red blood cells. Tuncel et al 13 reported high MPV values in patients with metastatic colorectal cancer. An MCV blood test is often part of a complete blood count (CBC). Osada et al 12 found significantly higher MPV values in gastric cancer patients than in healthy controls. Kurt et al 11 have reported that MPV is high in patients with hepatocellular cancer and may be a diagnostic marker for this cancer. 16 As the MPV is a significant predictor of platelet activation, 17 we hypothesized that MPV might be related to thyroid malignancies. 15 Activated platelets secrete angiogenic growth factors, which contribute to tumor angiogenesis and thereby promote tumor formation. Platelets have been suggested to play an important role in the progression and metastasis of cancer. Several clinical studies have investigated the association between platelet counts and survival times in cancer patients. Further prospective studies with a larger number of patients in high-volume endocrine surgery centers are required to confirm our findings. We propose that MPV might be an important predictive factor for thyroid malignancies. MPV was significantly higher in patients with thyroid malignancies than in patients with benign thyroid diseases. Age, sex, hemoglobin level, WBC count, and platelet count did not significantly differ between the 2 groups. MPV was significantly higher in patients with malignant thyroid diseases than in those with benign thyroid diseases. Data on age, sex, MPV, white blood cell (WBC) count, hemoglobin level, and platelet count were collected retrospectively. This study involved 146 patients who underwent total thyroidectomy because of benign (99 patients) or malignant (47 patients) diseases of the thyroid. Therefore, in conditions that involve increased platelet activation, an increase in the proportion of young platelets and MPV is expected. Large platelets are relatively new, more reactive, and produce more thrombogenic factors. Platelets differ in terms of functional activity and size. MPV is a useful early indicator of platelet activation. This study aimed to determine the relationship between mean platelet volume (MPV) and thyroid malignancy by comparing patients who underwent surgery for benign or malignant thyroid diseases.
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